Pangolin

ClinVar Database — NCBI's public archive of human genetic variant clinical significance. Query via E-utilities REST API (esearch, esummary, efetch, elink) or download bulk data from FTP in XML, VCF, a

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cyvcf2 — fast Cython-wrapped htslib library for reading, writing, and querying VCF/BCF variant files in Python. Provides numpy-backed genotype arrays (gt_types, gt_ref_depths, gt_alt_depths, gt_quals,

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Poetry is the Python dependency management and packaging tool for creating reproducible projects with pyproject.toml and poetry.lock. Use this skill for dependency resolution, virtual environment isol

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PubMed Database — NCBI's comprehensive biomedical literature database providing free access to over 37 million citations from MEDLINE, life science journals, and online books. Query via E-utilities RE

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Zarr — chunked, compressed N-dimensional arrays for Python with cloud-native storage. Provides hierarchical groups, pluggable compression codecs (Blosc, Zstd, Gzip), sharding for large-scale datasets,

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